[Ultrastructural studies and neutrophil myeloperoxidase determination in rats with acute 2,4-dichlorphenoxyacetic acid poisoning].

The aim of the work was to study changes in the ultrastructure and activity of different developing forms of cells in the neutrophil series in rat bone marrow during acute poisoning with 2,4-dichlorphenoxyacetic acid. The results of the study enabled determination of the influence of this herbicide on the process of granulogenesis in the neutrophils to be achieved. Disturbances of granulogenesis appeared in some cells of the experimental group II (160 mg of 2,4-D-acid/kg of body weight) and in most cells in the experimental group III (400 mg of 2,4-D-acid/kg). The disturbances manifested themselves mainly as a decrease in the number of primary and secondary granules in different developing forms of the neutrophil series. This decrease was associated with appearance of numerous cytoplasmic vacuoles. The results show that primary granules participate in phagocytosis.