生育酚在实验性肿瘤照射中的作用。剂量及给药方式的影响。

Tocopherol in irradiation of experimental neoplasms. Influence of dose and administration.

作者信息

Kågerud A, Peterson H I

出版信息

Acta Radiol Oncol. 1981;20(2):97-100. doi: 10.3109/02841868109130427.

Abstract

The influence of tocopherol, administered intramuscularly in different single doses, on the effect of local irradiation of a transplanted rat sarcoma was investigated. Tocopherol in doses of 5, 25 or 50 mg/100 g body weight enhanced significantly the tumour growth retardation induced by irradiation. Tocopherol in a dose of 100 mg/100 g body weight as a placebo preparation had no similar effect. The influence of tocopherol administered intramuscularly or orally in identical doses was similar.

摘要

研究了以不同单剂量肌肉注射生育酚对移植大鼠肉瘤局部照射效果的影响。体重每100克注射5毫克、25毫克或50毫克剂量的生育酚能显著增强照射诱导的肿瘤生长抑制。体重每100克注射100毫克剂量的生育酚作为安慰剂制剂则没有类似效果。肌肉注射和口服相同剂量生育酚的影响相似。