Günther R, Herold M, Halberg E, Halberg F
Peptides. 1980 Winter;1(4):387-90. doi: 10.1016/0196-9781(80)90019-4.
The effect of placebo and ACTH-1-17 (Synchrodyn, Hoechst) upon urinary free cortisol was examined at 5 different circadian stages on 10 men with Steinbrocker Stage II-III rheumatoid arthritis. A mean cosinor analysis of urinary cortisol data from the subjects prior to treatment with either ACTH or placebo revealed a statistically highly-significant rhythm. A circadian variation in a response of urinary free cortisol to a placebo was also seen. Moreover, the response of the midline-estimating statistic of rhythm (rhythm-adjusted circadian average) of urinary free cortisol to ACTH-1-17 by patients with rheumatoid arthritis is circadian rhythmic. This reactivity rhythm is out of phase with the spontaneous rhythm in urinary cortisol acrophases-in the tests limited thus far to midsummer. The further assessment of the circadian component in the context of broader interactions by rhythms with other frequencies in various conditions in health and disease is warranted by the demonstration of rhythms here presented for men with rheumatoid arthritis.
在10名处于斯坦布鲁克二期至三期类风湿性关节炎的男性患者中，于5个不同的昼夜节律阶段，研究了安慰剂和促肾上腺皮质激素1-17（同步素，赫斯特公司）对尿游离皮质醇的影响。对使用促肾上腺皮质激素或安慰剂治疗前受试者的尿皮质醇数据进行的平均余弦分析显示，存在统计学上高度显著的节律。还观察到尿游离皮质醇对安慰剂反应的昼夜变化。此外，类风湿性关节炎患者尿游离皮质醇的节律中线估计统计量（节律调整后的昼夜平均值）对促肾上腺皮质激素1-17的反应具有昼夜节律性。在目前仅限于仲夏的测试中，这种反应性节律与尿皮质醇高峰相位的自发节律不同步。鉴于此处展示的类风湿性关节炎男性患者的节律，有必要在更广泛的相互作用背景下，进一步评估健康和疾病各种情况下与其他频率节律的昼夜节律成分。
