Marques N, Sánchez de la Peña S, Ungar F, Halberg F
Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1988;21(4):759-62.
The objective of the present study was to determine the circadian effects of melatonin and two different ACTH preparations: a synthetic heptadecapeptide with adrenocorticotrophic action (Synchrodyn 1-17, HOE 433) and a natural ACTH (Acthar, Armour). Both ACTH preparations acted in a circadian stage-dependent fashion affecting the MESOR and the amplitude of total protein synthesis of rat adrenal cells. The results also indicated interaction of melatonin with the rhythmic action of ACTH. We conclude that circadian adrenocortical organization also modulates protein synthesis.
一种具有促肾上腺皮质作用的合成十七肽（Synchrodyn 1 - 17，HOE 433）和一种天然促肾上腺皮质激素（Acthar，Armour）。两种促肾上腺皮质激素制剂均以昼夜节律阶段依赖性方式发挥作用，影响大鼠肾上腺细胞总蛋白合成的中值（MESOR）和幅度。结果还表明褪黑素与促肾上腺皮质激素的节律性作用存在相互作用。我们得出结论，昼夜节律性肾上腺皮质组织也调节蛋白质合成。
