Hill T L, Tsuchiya T
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4796-800. doi: 10.1073/pnas.78.8.4796.
The basic kinetic and bioenergetic theory is outlined for two kinds of translocation on DNA: (i) helicases that use ATP to move along single-stranded DNA or to move on and invade double-stranded DNA at a replication fork; and (ii) DNA-binding proteins (not ATPases) that form bound aggregates on single-stranded DNA and facilitate replication by steady-state treadmilling of molecules between the ends of the aggregate. The respective resemblances to myosin--actin in muscle and to steady-state treadmilling in solution of actin or tubulin are pointed out.
本文概述了DNA上两种转位作用的基本动力学和生物能量学理论：（i）解旋酶，利用ATP沿着单链DNA移动，或在复制叉处移动并侵入双链DNA；（ii）DNA结合蛋白（非ATP酶），在单链DNA上形成结合聚集体，并通过聚集体两端分子的稳态踏车运动促进复制。文中指出了它们分别与肌肉中肌球蛋白-肌动蛋白以及肌动蛋白或微管蛋白溶液中的稳态踏车运动的相似之处。
