微丝或微管在力的作用下进行组装或拆卸。
Microfilament or microtubule assembly or disassembly against a force.
作者信息
Hill T L
出版信息
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5613-7. doi: 10.1073/pnas.78.9.5613.
Abstract
Microtubules (tubulin) or bundles of microfilaments (actin) are thought to cause movement, in some instances, by disassembly or assembly of subunits. Possible examples are the pulling of a chromosome toward a pole in mitosis (anaphase) or the deformation of a cell membrane to change the shape of a cell. This paper examines the relevant elementary bioenergetic considerations when assembly or disassembly of an aggregate occurs against a resisting force. The problem is considered, in the first section, without NTPase activity. Sickle cell hemoglobin aggregation in vivo is an example. In the second section, the tubulin GTPase and actin ATPase activities are included in the analysis.
摘要
微管（微管蛋白）或微丝束（肌动蛋白）在某些情况下被认为是通过亚基的拆卸或组装来引起运动的。可能的例子有有丝分裂（后期）中染色体向极的牵拉或细胞膜变形以改变细胞形状。本文研究了在有阻力的情况下聚集体组装或拆卸时相关的基本生物能量学因素。在第一部分中，不考虑NTPase活性来考虑这个问题。体内镰状细胞血红蛋白聚集就是一个例子。在第二部分中，分析中纳入了微管蛋白GTPase和肌动蛋白ATPase活性。
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本文引用的文献
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Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning.秋水仙碱 - 微管蛋白复合物添加到微管末端：亚化学计量秋水仙碱中毒的机制。
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