胆囊收缩素八肽通过诱导高血糖来抑制应激诱导的进食。
Cholecystokinin-octapeptide suppresses stress-induced eating by inducing hyperglycemia.
作者信息
Levine A S, Morley J E
出版信息
Regul Pept. 1981 Nov;2(6):353-7. doi: 10.1016/0167-0115(81)90017-3.
PMID:6272376
Abstract
Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestrained rats suppressed stress-induced eating and produced hyperglycemia. Prior adrenalectomy markedly reduced the hyperglycemia effect of intraventricular CCK-8 and also decreased the suppressive effect of CCK-8 on stress-induced eating. Our data are compatible with the anorectic effect of CCK-8 being secondary to the hyperglycemia it produces.
摘要
在未麻醉、未束缚的大鼠中，脑室内注射胆囊收缩素八肽（CCK-8）可抑制应激诱导的进食并导致高血糖。预先进行肾上腺切除术可显著降低脑室内CCK-8的高血糖效应，同时也降低了CCK-8对应激诱导进食的抑制作用。我们的数据表明，CCK-8的厌食作用继发于其产生的高血糖。
Zotero 插件