Lorenz D N, Goldman S A
Physiol Behav. 1982 Oct;29(4):599-604. doi: 10.1016/0031-9384(82)90226-8.
Central (intracerebroventricular) and peripheral (intraperitoneal) injections of the octapeptide of cholecystokinin (CCK-8) were compared to determine the most effective route of administration to elicit satiety for food intake in the rat. Subdiaphragmatic bilateral vagotomy and spinal cordotomy (T2-T3) were also performed to investigate the importance of visceral nerves for the satiety effect. CCK-8 suppressed feeding and elicited satiety resting behavior when injected peripherally but it was less effective when injected centrally. The satiety effect of CCK-8 or CCK-33 following peripheral injections was blocked by vagotomy whereas spinal cordotomy had no effect. The results indicate that some component of the vagus is required to mediate the peripherally induced cholecystokinin satiety effect, but the splanchnic nerves are not necessary. The weak effect of CCK-8 following ventricular administration is additional evidence suggesting that cholecystokinin of intestinal origin acts in the periphery rather than directly on the brain to elicit its typically rapid satiety effect in rats.
比较了胆囊收缩素八肽（CCK - 8）的中枢（脑室内）注射和外周（腹腔内）注射，以确定在大鼠中引发食物摄入饱腹感的最有效给药途径。还进行了膈下双侧迷走神经切断术和脊髓切断术（T2 - T3），以研究内脏神经对饱腹感效应的重要性。CCK - 8外周注射时可抑制进食并引发饱腹感静息行为，但中枢注射时效果较差。外周注射CCK - 8或CCK - 33后的饱腹感效应被迷走神经切断术阻断，而脊髓切断术则无影响。结果表明，迷走神经的某些成分是介导外周诱导的胆囊收缩素饱腹感效应所必需的，但内脏神经并非必需。脑室给药后CCK - 8的微弱效应进一步证明，肠道来源的胆囊收缩素在大鼠中是在外周起作用，而非直接作用于大脑来引发其典型的快速饱腹感效应。
