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垂体中间叶提取物对分离的肾小球带和束状带细胞类固醇生成的影响。

Effect of pituitary intermediate lobe extract on steroid production by the isolated zona glomerulosa and fasciculata cells.

作者信息

Szalay K S

出版信息

Acta Physiol Acad Sci Hung. 1981;57(3):225-31.

PMID:6272545
Abstract

The effect of intermediate lobe extract (ILE) on aldosterone and corticosterone production of the zona glomerulosa cells and on corticosterone production of the zona fasciculata cells was investigated. The slope of the dose-response curve of ILE dilution was steeper than that of alpha h 1-39 ACTH measured on zona glomerulosa steroid production. The ED50 of both ILE and ACTH was lower when measured on zona glomerulosa than on zona fasciculata steroid production. It is supposed that a hormone (or some other substance) in ILE alters the sensitivity to ACTH of the zona glomerulosa cells.

摘要

研究了中间叶提取物（ILE）对球状带细胞醛固酮和皮质酮生成以及束状带细胞皮质酮生成的影响。在球状带类固醇生成方面，ILE稀释的剂量-反应曲线斜率比α h 1-39促肾上腺皮质激素（ACTH）的更陡。在球状带测量时，ILE和ACTH的半数有效剂量（ED50）均低于在束状带类固醇生成时的测量值。据推测，ILE中的一种激素（或其他某种物质）改变了球状带细胞对ACTH的敏感性。

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Stereological and functional investigations on isolated adrenocortical cells: zona fasciculata/reticularis cells of chronically ACTH-treated rats.对分离的肾上腺皮质细胞的体视学和功能研究：长期接受促肾上腺皮质激素治疗大鼠的束状带/网状带细胞
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Stereological and functional investigations on isolated adrenocortical cells. III. Zona glomerulosa cells of chronically ACTH-treated rats.
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J Anat. 1990 Feb;168:199-207.
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A mechanism of the influence of interleukin-1 on blood glucocorticoid level: absence of a direct effect of interleukin-1 on adrenal cortical cells.
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The effects of ageing on the morphology and function of the zonae fasciculata and reticularis of the rat adrenal cortex.衰老对大鼠肾上腺皮质束状带和网状带形态及功能的影响。
Cell Tissue Res. 1992 Nov;270(2):265-72. doi: 10.1007/BF00328012.