Payet N, Lehoux J G
J Physiol (Paris). 1982;78(3):317-21.
An interaction between ACTH and vasopressin on steroidogenesis was observed in isolated rat adrenal zona glomerulosa cell preparations. 1. The presence of 10(-11) M vasopressin further increased by 52% the output of aldosterone produced by 10(-12) M ACTH on those cells. 2. At a pharmacological concentration of ACTH (10(-7) M), the aldosterone output was increased 5 fold while the addition of 10(-12) M or 10(-8) M vasopressin decreased it by 17% and 48% respectively. 3. Vasopressin also produced a dose-dependent inhibition of the stimulatory effect of ACTH on the output of corticosterone. 4. We have thus shown for the first time, that vasopressin acts directly on adrenal zona glomerulosa cell preparations to modify the aldosterone output by modulating the action of ACTH. It is postulated that, in addition to other known aldosterone regulating factors, ACTH and vasopressin might synergistically act to regulate the secretion of aldosterone in vivo.
在分离的大鼠肾上腺球状带细胞制剂中观察到促肾上腺皮质激素（ACTH）和血管加压素对类固醇生成的相互作用。1. 10(-11) M血管加压素的存在使10(-12) M ACTH在这些细胞上产生的醛固酮产量进一步增加了52%。2. 在ACTH的药理浓度（10(-7) M）下，醛固酮产量增加了5倍，而添加10(-12) M或10(-8) M血管加压素分别使其降低了17%和48%。3. 血管加压素还对ACTH刺激皮质酮产量的作用产生剂量依赖性抑制。4. 因此，我们首次表明，血管加压素直接作用于肾上腺球状带细胞制剂，通过调节ACTH的作用来改变醛固酮产量。据推测，除了其他已知的醛固酮调节因子外，ACTH和血管加压素可能协同作用以在体内调节醛固酮的分泌。
