Maloney M A, Patt H M
Exp Hematol. 1978 Feb;6(2):227-32.
The early migration of stem cells from a shielded marrow to an irradiated spleen has been re-evaluated, and the findings have been compared with the results of earlier studies. The composite data reveal a constant rate during the first 24 h after irradiation, with a slope of 1.6 cells per h and an intercept of 2.4. The positive intercept is interpreted to signify an immediate brief perturbation of CFU's release. The low concentration of CFUs in the bloodstream, despite their continuous migration from the shielded marrow, is indicative of a rapid, and probably greatly increased, blood turnover. Despite the constancy of stem cell seeding, it is not yet possible to determine whether the rate of stem cell release is different in shielded marrow than in normal marrow. The resolution of this question requires more precise information about spleen seeding efficiency in the autorepopulation assay and about the normal turnover rate of stem cells in the bloodstream.
干细胞从受保护的骨髓向受辐照脾脏的早期迁移已被重新评估，并将结果与早期研究结果进行了比较。综合数据显示，辐照后最初24小时内速率恒定，斜率为每小时1.6个细胞，截距为2.4。正截距被解释为意味着集落形成单位（CFU）释放的即刻短暂扰动。尽管CFU从受保护的骨髓持续迁移，但血流中CFU浓度较低，这表明血液周转率很快，而且可能大幅增加。尽管干细胞播种率恒定，但尚无法确定受保护骨髓中干细胞释放速率与正常骨髓中是否不同。要解决这个问题，需要关于自身再增殖试验中脾脏播种效率以及血流中干细胞正常周转率的更精确信息。
