Yiannikas C, Pollard J D, McLeod J G
Aust N Z J Med. 1981 Aug;11(4):400-5. doi: 10.1111/j.1445-5994.1981.tb03521.x.
Four cases of severe peripheral neuropathy directly attributable to nitrofurantoin are reported. The neuropathy was not dose-related and not necessarily associated with abnormal renal function. Recovery was slow, and neither severity nor recovery was related to the total dose of the drug. The pathological changes seen on light microscopy and electron microscopy were those of acute, severe axonal degeneration. It is emphasised that nitrofurantoin is a neurotic drug and should not be prescribed to the elderly not to anyone with impairment of renal function.
报告了4例直接归因于呋喃妥因的严重周围神经病变。该神经病变与剂量无关，也不一定与肾功能异常相关。恢复缓慢，严重程度和恢复情况均与药物总剂量无关。光镜和电镜下所见的病理变化为急性、严重的轴突变性。强调呋喃妥因是一种可导致神经病变的药物，不应开给老年人或任何肾功能受损者。
