Mascellino M T, Prignano G, Iegri F, Delia S
Boll Ist Sieroter Milan. 1981 May;60(2):102-9.
HR 756 is a new beta-lactamase resistant cephalosporin. The activity of HR 756 was compared in vitro to that of cefamandole, cefoxitine, cefuroxime and cephalothin. A concentration of 1 microgram/ml inhibited practically all isolates of E. coli, Salmonella, Shigella, Proteus indole + and indole --, Klebsiella, etc. A lower activity in vitro has been found regarding to Enterobacter, Serratia, Citrobacter and Pasteurella. The cefotaxime has some anti-Pseudomonas activity at concentrations of 7.5-15 micrograms/ml. For most Gram-negative organisms, HR 756 was most active. The cephalothin and the cefoxitine have resulted more active regard to Staph. aureus and Bacteroides fragilis, respectively.
HR 756是一种新型的耐β-内酰胺酶头孢菌素。将HR 756的体外活性与头孢孟多、头孢西丁、头孢呋辛和头孢噻吩进行了比较。1微克/毫升的浓度实际上能抑制所有大肠杆菌、沙门氏菌、志贺氏菌、吲哚阳性和吲哚阴性变形杆菌、克雷伯氏菌等菌株。对于肠杆菌、沙雷氏菌、柠檬酸杆菌和巴斯德氏菌，已发现其体外活性较低。头孢噻肟在7.5 - 15微克/毫升的浓度下具有一定的抗假单胞菌活性。对于大多数革兰氏阴性菌，HR 756活性最强。头孢噻吩和头孢西丁分别对金黄色葡萄球菌和脆弱拟杆菌的活性更高。
