Levine A S, Morley J E, Kneip J, Grace M, Silvis S E
Brain Res. 1981 Dec 14;229(1):270-4. doi: 10.1016/0006-8993(81)90770-8.
Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occurred in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of D-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric acid secretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.
向幽门结扎大鼠脑室内注射γ-氨基丁酸（GABA）激动剂蝇蕈醇，可导致胃酸分泌呈剂量依赖性增加。胃酸分泌的最大增加出现在第二小时。GABA拮抗剂甲磺酸荷包牡丹碱可逆转蝇蕈醇对胃酸分泌的作用。向脑室内注射D-丙氨酸甲硫氨酸脑啡肽、蛙皮素和降钙素可显著抑制蝇蕈醇诱导的胃酸分泌。本研究表明，GABA能系统在胃酸分泌的中枢控制中发挥作用。
