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皮质醇在其糖原生成作用之前的早期效应。

An early effect of cortisol, previous to its glycogenogenic action.

作者信息

Egaña M, Sancho M J, Macarulla J M

出版信息

Horm Metab Res. 1981 Nov;13(11):609-11. doi: 10.1055/s-2007-1019351.

DOI:10.1055/s-2007-1019351
PMID:6273276
Abstract

Cortisol produces a glycogenogenic effect 5 hours after intraperitoneal injection to 3 day old chicks. This effect is dependent on protein synthesis because it can be blocked by antibiotics such as actinomycin D. On the other hand, there is a previous glycogenolytic effect 45 minutes after cortisol administration which is independent of protein synthesis. Thyroid hormones produce a similar early effect as has been previously shown. However, the observed glycogenolysis after cortisol injection is not correlated with an enhancement in the liver cAMP levels.

摘要

对3日龄雏鸡腹腔注射皮质醇5小时后会产生糖原生成效应。这种效应依赖于蛋白质合成,因为它可被放线菌素D等抗生素阻断。另一方面,在给予皮质醇45分钟后会有先前的糖原分解效应,该效应与蛋白质合成无关。甲状腺激素会产生如先前所示的类似早期效应。然而,注射皮质醇后观察到的糖原分解与肝脏环磷酸腺苷(cAMP)水平的升高并无关联。

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1
An early effect of cortisol, previous to its glycogenogenic action.皮质醇在其糖原生成作用之前的早期效应。
Horm Metab Res. 1981 Nov;13(11):609-11. doi: 10.1055/s-2007-1019351.
2
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An early effect of estradiol at hepatic level, previous to its protein synthesis activation.在其激活蛋白质合成之前,雌二醇在肝脏水平产生的早期效应。
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[Proceedings: Cortisol-dependent glycogen storage and responses to insulin and glucagon in rat fetal cultured hepatocytes (author's transl)].[会议论文:大鼠胎儿培养肝细胞中皮质醇依赖性糖原储存及对胰岛素和胰高血糖素的反应(作者译)]
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Endocrinology. 1990 Oct;127(4):1867-76. doi: 10.1210/endo-127-4-1867.

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J Endocrinol Invest. 2009 Oct;32(9):756-8. doi: 10.1007/BF03346532.
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Rapid activation of glycogen phosphorylase by steroid hormones in cultured rat hepatocytes.甾体激素对培养的大鼠肝细胞中糖原磷酸化酶的快速激活作用。
Biochem J. 1989 Sep 1;262(2):417-23. doi: 10.1042/bj2620417.
3
Evidence for the presence of specific binding sites for corticoids in mouse liver plasma membranes.小鼠肝细胞膜中存在皮质激素特异性结合位点的证据。
J Membr Biol. 1989 May;108(2):115-24. doi: 10.1007/BF01871023.
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Steroid hormone specifically binds to rat kidney plasma membrane.类固醇激素特异性结合大鼠肾细胞膜。
J Bioenerg Biomembr. 1991 Dec;23(6):919-26. doi: 10.1007/BF00786009.
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Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes.孕酮和雌二醇可增加单个大鼠肝细胞中的胞质钙离子浓度。
Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):273-6. doi: 10.1042/bj2800273.