Suzuki M, Simizu B, Yabe S, Oya A, Seto H
Toxicol Lett. 1981 Nov;9(3):231-5. doi: 10.1016/0378-4274(81)90155-7.
When mice were treated with 0.09 mg cadmium chloride (Cd) per mouse once and inoculated i.p. simultaneously with Japanese encephalitis virus (JEV) they showed a significant difference in the incubation time and mortality between the treated and untreated groups in repeated experiments. Cd treatment shortened the incubation time and the mortality increased greater than twice compared with the untreated control. This effect was not observed in the case of intracerebral inoculation of JEV. Effects of Cd on antibody formation in mice were also determined. Animals given a single s.c. dose of Cd were immunized with JE inactivated vaccine once simultaneously. When mice were treated with Cd, they did not show low neutralizing and hemagglutination inhibition activities compared with the control mice. Pretreatment of Cd did not affect any mortality or antibody formation.
当给小鼠每只单次腹腔注射0.09毫克氯化镉（Cd）并同时腹腔接种日本脑炎病毒（JEV）时，在重复实验中，处理组和未处理组在潜伏期和死亡率上显示出显著差异。与未处理的对照组相比，Cd处理缩短了潜伏期，死亡率增加了两倍多。在脑内接种JEV的情况下未观察到这种效应。还测定了Cd对小鼠抗体形成的影响。给单次皮下注射Cd的动物同时单次用乙脑灭活疫苗进行免疫。当用Cd处理小鼠时，与对照小鼠相比，它们没有表现出低中和及血凝抑制活性。Cd预处理不影响任何死亡率或抗体形成。
