Milev N, Pavlov N, Panaiotov P, Nikolova Z
Vet Med Nauki. 1981;18(4):10-6.
Studies were carried out on the first grippe epizootic in pigs in Bulgaria. The affected animals showed a rise in temperature (40.5 to 41.8 degrees C), loss of appetite, abdominal type of respiration, and noisy and painful cough. The infection ran its course with a picture typical of a virus disease which did not respond to broad-spectrum antibiotic treatment. On an average the duration of the clinical course lasted 4 to 5 days, affecting almost all swine on a pig breeding farm, with single death cases. The morphologic changes observed in animals killed for diagnostic purposes were typical of a grippe infection. Isolated was a grippe virus A (Antimovo) 1/80/H3N2) the preliminary typisation of which showed close relation to strain A (victoria) 3/75/H3N2/. Serologic investigations using double blood samples from the affected pigs in double immunodiffusion test and hemagglutination-inhibition test demonstrated the etiologic role played by the isolated grippe virus.
针对保加利亚猪群中首次出现的流感疫情展开了研究。受感染的动物体温升高（40.5至41.8摄氏度），食欲不振，出现腹式呼吸，伴有呼噜声且咳嗽时疼痛。感染呈现出典型的病毒病症状，对广谱抗生素治疗无反应。临床病程平均持续4至5天，几乎影响到养猪场的所有猪只，有个别死亡病例。为诊断目的宰杀的动物所观察到的形态学变化是流感感染的典型表现。分离出一株甲型流感病毒（安蒂莫沃）1/80/H3N2，其初步分型显示与A（维多利亚）3/75/H3N2毒株密切相关。使用来自受感染猪的双份血液样本进行双向免疫扩散试验和血凝抑制试验的血清学调查证实了分离出的流感病毒所起的病因学作用。
