Hossfeld D K, Schmidt C G
Int J Cancer. 1978 Feb 15;21(2):147-56. doi: 10.1002/ijc.2910210204.
Effusion cells from six patients with advanced Hodgkin's disease were studied. Even though no Hodgkin or Reed-Sternberg cells could be identified cytologically in five of the six cases, striking chromosome anomalies of a clonal nature, including a number of recurrent marker chromosomes, were demonstrated in all effusions. It is concluded that the effusion cells with abnormal karyotypes were intimately related to the pathogenesis of Hodgkin's disease.
对6例晚期霍奇金病患者的积液细胞进行了研究。尽管在6例中的5例细胞学检查中未发现霍奇金或里德-施特恩贝格细胞，但在所有积液中均显示出具有克隆性质的显著染色体异常，包括一些反复出现的标记染色体。得出的结论是，核型异常的积液细胞与霍奇金病的发病机制密切相关。
