Schramm V L, Srodes C, Myers E N
Arch Otolaryngol. 1981 Dec;107(12):739-41. doi: 10.1001/archotol.1981.00790480015004.
Adenoid cystic carcinoma of salivary gland origin is a relentless disease that produces a high rate of local recurrence, metastases, and death, regardless of the type of treatment. There have been few previous reports of effective chemotherapy. Cisplatin has been chosen for a trial in the treatment of patients with persistent, recurrent, or metastatic adenoid cystic carcinoma because of its demonstrated activity against a variety of tumor types, especially those with a low growth fraction. Ten patients have been included in a pilot study. Seventy percent of these patients have had a favorable subjective response and objective tumor regression. Further clinical trials are suggested.
涎腺来源的腺样囊性癌是一种难治性疾病，无论采用何种治疗方式，其局部复发、转移和死亡率都很高。以往关于有效化疗的报道很少。顺铂因其对多种肿瘤类型，尤其是生长分数低的肿瘤具有显著活性，已被选用于治疗持续性、复发性或转移性腺样囊性癌患者的试验。一项初步研究纳入了10名患者。这些患者中有70%出现了良好的主观反应和客观肿瘤消退。建议进一步开展临床试验。
