腺病毒12型DNA转化早期区域E1b的核苷酸序列：结构与基因组织，以及与腺病毒5型DNA的比较
Nucleotide sequence of the transforming early region E1b of adenovirus type 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA.
作者信息
Kimura T, Sawada Y, Shinawawa M, Shimizu Y, Shiroki K, Shimojo H, Sugisaki H, Takanami M, Uemizu Y, Fujinaga K
出版信息
Nucleic Acids Res. 1981 Dec 11;9(23):6571-89. doi: 10.1093/nar/9.23.6571.
Abstract
The nucleotide sequence of the entire transforming early region of E1b of the highly oncogenic adenovirus type 12 (Ad12) DNA has been determined. The total sequence (3860 base pairs) encompasses the entire transforming early region E1 of Ad12 DNA. From the sequence for the E1b region of Ad12, and the transcription map of the E1b region (1, 2, 3, and this paper) the structure and gene organization of the early region E1b of Ad12 DNA were analyzed and compared with those of the E1b region in the non-oncogenic Ad5 DNA (4, 5). Most of the sequences in the E1b region of Ad12 was highly homologous to that of Ad5. It is predicted that the Ad12 region E1b codes for polypeptides of 53.9, 19.1, and 8.9 kd. This situation is identical with that of the Ad5 region E1b which codes for polypeptides of 54.9, 20.6, and 8.3 kd. The function of these predicted polypeptides encoded by the E1b regions in cell transformation is discussed.
摘要
已确定高致癌性12型腺病毒（Ad12）DNA的E1b整个转化早期区域的核苷酸序列。总序列（3860个碱基对）涵盖了Ad12 DNA的整个转化早期区域E1。根据Ad12的E1b区域序列以及E1b区域的转录图谱（参考文献1、2、3以及本文），分析了Ad12 DNA早期区域E1b的结构和基因组织，并与非致癌性Ad5 DNA的E1b区域进行了比较（参考文献4、5）。Ad12的E1b区域中的大多数序列与Ad5的高度同源。预计Ad12区域E1b编码53.9、19.1和8.9千道尔顿的多肽。这种情况与Ad5区域E1b相同，后者编码54.9、20.6和8.3千道尔顿的多肽。讨论了由E1b区域编码的这些预测多肽在细胞转化中的功能。
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本文引用的文献
1
Eukaryotic promoters?真核生物启动子？
Nature. 1979 May 31;279(5712):376. doi: 10.1038/279376a0.
2
BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION, VI. PROPERTIES OF HIGHLY PURIFIED TUMORIGENIC HUMAN ADENOVIRUSES AND THEIR DNA.腺病毒增殖的生化研究，VI. 高度纯化的致瘤人类腺病毒及其DNA的特性
Proc Natl Acad Sci U S A. 1964 Jun;51(6):1251-9. doi: 10.1073/pnas.51.6.1251.
3
Biochemical studies on adenovirus multiplication. IV. Isolation, purification, and chemical analysis of adenovirus.腺病毒增殖的生化研究。IV. 腺病毒的分离、纯化及化学分析。
Virology. 1963 May;20:199-207. doi: 10.1016/0042-6822(63)90157-0.
4
Mapping of adenovirus 12 mRNA's transcribed from the transforming region.对从转化区转录的腺病毒12信使核糖核酸的图谱分析。
J Virol. 1980 Dec;36(3):639-51. doi: 10.1128/JVI.36.3.639-651.1980.
5
Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses.野生型和突变型腺病毒转化区的蛋白质和信使核糖核酸
J Mol Biol. 1980 Sep 25;142(3):399-417. doi: 10.1016/0022-2836(80)90279-x.
6
Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications.12型腺病毒两种转化多肽的结构及其进化意义
Nature. 1980 Nov 13;288(5787):174-6. doi: 10.1038/288174a0.
7
Identification and mapping of the early gene products of adenovirus type 12.腺病毒12型早期基因产物的鉴定与定位
Virology. 1980 Sep;105(2):551-63. doi: 10.1016/0042-6822(80)90055-0.
8
Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.腺病毒5型DNA最左端4.5%的片段对原代大鼠细胞的部分转化
Virology. 1980 Sep;105(2):537-50. doi: 10.1016/0042-6822(80)90054-9.
9
Identification of the adenovirus early proteins and their genomic map positions.腺病毒早期蛋白的鉴定及其基因组图谱位置
Virology. 1980 Jan 30;100(2):419-32. doi: 10.1016/0042-6822(80)90533-4.
10
Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses.人腺病毒A、B和C亚组早期E1a区域核苷酸序列的比较。
Gene. 1980 Dec;12(1-2):63-76. doi: 10.1016/0378-1119(80)90016-5.
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