Olson J G, Ksiazek T G
Trans R Soc Trop Med Hyg. 1981;75(3):389-93. doi: 10.1016/0035-9203(81)90100-0.
In 1977 and 1978 selected in-patients at the Tegalyoso Hospital, Klaten, Indonesia who had recent onsets of acute fever were serologically studied for evidence for alphavirus and flavivirus infections. A brief clinical history was taken and a check list of signs and symptoms was completed on admission. Acute and convalescent phase sera from 30 patients who showed evidence that a flavivirus had caused their illnesses were tested for neutralizing antibodies to several flaviviruses which occur in South-east Asia. Paired sera from seven patients demonstrated a fourfold rise in antibody titre from acute to convalescent phase. The most common clinical manifestations observed in this series of patients included high fever, malaise, stomach ache, dizziness and anorexia. None of the seven patients had headache or rash despite the fact that headache and rash had been associated with two of the three previously studied. The onsets of illness clustered toward the end of the rainy season when populations of Aedes aegypti, a probable vector in Malaysia, were most abundant.
1977年和1978年，对印度尼西亚克拉滕市特加约索医院近期出现急性发热的部分住院患者进行了血清学研究，以寻找甲病毒和黄病毒感染的证据。记录了简要的临床病史，并在入院时完成了体征和症状检查表。对30例有证据表明由黄病毒引起疾病的患者的急性期和恢复期血清进行检测，以检测其对几种在东南亚出现的黄病毒的中和抗体。7例患者的配对血清显示抗体滴度从急性期到恢复期有四倍升高。在这组患者中观察到的最常见临床表现包括高热、不适、胃痛、头晕和厌食。这7例患者均无头痛或皮疹，尽管在之前研究的三例患者中有两例出现过头痛和皮疹。疾病发作集中在雨季末期，此时埃及伊蚊（马来西亚可能的传播媒介）数量最多。
