Hazard P B, Griffin J P
Am J Med Sci. 1982 Jan-Feb;283(1):18-22. doi: 10.1097/00000441-198201000-00003.
Despite the host of complications which may be associated with intravenous sodium bicarbonate infusion, the use of this agent is a frequent necessity in patients with metabolic acidosis. No satisfactory formula for calculating bicarbonate dose had previously been described, although such an approach might be expected to reduce the incidence of these complications. The authors have devised a simple formula for bedside calculation of bicarbonate requirement in metabolic acidosis, designed to elevate th pH to the region about 7.30, and report their experience with the use of this formula in 13 instances. In all but one, the post-infusion pH was between 7.25 and 7.37, with a mean of 7.30 +/- 0.04 and no instances of serious overtitration. It is concluded that the formula is useful as a pragmatic aid in the management of patients with metabolic acidosis.
尽管静脉输注碳酸氢钠可能会引发一系列并发症，但对于患有代谢性酸中毒的患者而言，使用该药物却常常是必要之举。此前尚未有令人满意的计算碳酸氢盐剂量的公式被描述出来，尽管人们期望这样一种方法或许能够降低这些并发症的发生率。作者们设计出了一个用于床边计算代谢性酸中毒患者碳酸氢盐需求量的简单公式，旨在将pH值提升至约7.30的范围，并报告了他们在13例病例中使用该公式的经验。除1例之外，所有病例输注后的pH值均在7.25至7.37之间，平均值为7.30±0.04，且没有出现严重滴定过量的情况。得出的结论是，该公式作为一种实用的辅助手段，在代谢性酸中毒患者的治疗中很有用。
