Bel A, Girard D
Sem Hop. 1981;57(47-48):1992-6.
Eight cases of hepatitis induced by amineptine chlorhydrate, a new tricyclic antidepressant are reported. Jaundice and/or biological changes occurred 16 to 75 days after the onset of treatment and with a total oral dose of 3,8 to 26 grams. Biologically, cholestasis and cytolysis have been observed simultaneously in 4 cases, cholestasis alone in 2 cases, and prevalent cytolysis in 2 others. After withdrawal of amineptine, clinical improvement was achieved within 10 to 21 days, whereas biological changes of hepatic function tests lasted for as long as 3 to 12 weeks. Physiopathology of such disorders is not clear : toxicity, enzyme induction, immunoallergy, may be considered as possible mechanisms.
报告了8例由新型三环类抗抑郁药盐酸阿密替林引起的肝炎病例。黄疸和/或生物学变化发生在治疗开始后16至75天，口服总剂量为3.8至26克。从生物学角度看，4例同时观察到胆汁淤积和细胞溶解，2例仅出现胆汁淤积，另外2例则以细胞溶解为主。停用阿密替林后，10至21天内临床症状有所改善，而肝功能测试的生物学变化则持续长达3至12周。此类疾病的病理生理学尚不清楚：毒性、酶诱导、免疫过敏等都可能是潜在机制。
