Murad T M, Contesso G, Mouriesse H
Ann Surg. 1982 Mar;195(3):259-64. doi: 10.1097/00000658-198203000-00003.
Abnormal nipple discharge is rare, constituting only 3-5% of mammary consultation. In the present paper 267 patients with primary nipple discharge operated on at Institut Gustave-Roussay (IGR) in Villejuif, France, between January 1, 1960 and December, 1974 were evaluated. In all cases, the nipple discharge was symptomatic, spontaneous, and represented the primary reason for the patient's consultation. During the same period 1,145 cases of nipple discharge were treated at IGR. Of the 1,145 cases with symptomatic nipple discharge, 267 patients (23%) required surgical intervention. Among these, fibrocystic disease and duct ectasia were the leading causes of nipple discharge occurring in 42% of surgical specimens. Twenty one per cent of the patients had carcinoma and 35% were found to have intraductal papilloma. The overall incidence of malignancy, however, was 4.8% among the 1,145 women with nipple discharge. On the average, patients with nipple discharge due to malignancy were ten years older than those with benign lesions (Table 2). Approximately 25% of patients with malignant discharge and 5% with benign discharge have associated tumor. Over 60% of the patients with both discharge and a mass had malignancy.
乳头溢液并不常见，仅占乳腺门诊病例的3% - 5%。本文对1960年1月1日至1974年12月期间在法国维勒瑞夫古斯塔夫 - 鲁西研究所（IGR）接受手术治疗的267例原发性乳头溢液患者进行了评估。在所有病例中，乳头溢液均有症状，为自发性，且是患者就诊的主要原因。同一时期，IGR共治疗了1145例乳头溢液病例。在1145例有症状的乳头溢液病例中，267例（23%）患者需要手术干预。其中，纤维囊性疾病和导管扩张是乳头溢液的主要原因，在42%的手术标本中出现。21%的患者患有癌症，35%的患者发现有导管内乳头状瘤。然而，在1145例乳头溢液女性中，恶性肿瘤的总体发病率为4.8%。平均而言，因恶性肿瘤导致乳头溢液的患者比良性病变患者大10岁（表2）。约25%的恶性溢液患者和5%的良性溢液患者伴有肿瘤。超过60%有溢液且有肿块的患者患有恶性肿瘤。
