Melding P S, Goodey R J, Thorne P R
J Laryngol Otol. 1978 Feb;92(2):115-21. doi: 10.1017/s002221510008511x.
The effect of intravenous lignocaine upon the symptom of tinnitus has been assessed in seventy-eight patients and the results correlated with associated hearing loss. Lignocaine appears to be highly effective in suppressing tinnitus in patients with presumed damage or degeneration of the Organ of Corti and is less effective in other groups. It is postulated that tinnitus in patients with Organ of Corti damage is the result of abnormal hyperactivity in the auditory pathway following deafferentation.
已对78例患者评估了静脉注射利多卡因对耳鸣症状的影响,并将结果与相关听力损失进行了关联分析。利多卡因似乎对推测有柯蒂氏器损伤或退变的患者抑制耳鸣非常有效,而对其他组的效果较差。据推测,柯蒂氏器损伤患者的耳鸣是去传入后听觉通路异常活动亢进的结果。