[氧气、二氧化碳及钙离子对脑动脉平滑肌舒张机制的调控]
[Oxygen, carbon dioxide and calcium control of the mechanisms of relaxation in the cerebral artery smooth musculature].
作者信息
Azin A L
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1982 Jan;68(1):59-63.
PMID:6277705
Abstract
The direct action of the hypoxic (PO2 60-20 mm Hg) and hypercapnic (PCO2 50-60 mm Hg) solutions on isolated strips of human cerebral arteries was studied. Verapamil, sodium nitroprusside, manganese, dichlordiphenyltrichlomethylmethan inhibited the hypoxic and hypercapnic relaxation. The data obtained suggest that lowering of PO2 or raising of PCO2 decrease the membrane calcium transport and increase the activity of the cellular calcium pump.
摘要
研究了低氧（PO2 60 - 20 mmHg）和高碳酸血症（PCO2 50 - 60 mmHg）溶液对人脑动脉离体条带的直接作用。维拉帕米、硝普钠、锰、二氯二苯三氯甲烷抑制低氧和高碳酸血症引起的舒张。所得数据表明，PO2降低或PCO2升高会减少膜钙转运并增加细胞钙泵的活性。
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Fiziol Zh SSSR Im I M Sechenova. 1982 Jan;68(1):59-63.
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