Krasil'nikov V G, Artem'eva A I
Fiziol Zh SSSR Im I M Sechenova. 1982 Aug;68(8):1130-6.
In anesthetized cats, under perfusion and with constant volume of the hemodynamically isolated brain, hypercapnia and hypoxia led to a decrease of cerebral vessels resistance and to a reduction of the brain blood flow, whereas a decrease in the PCO2 and an increase in the PO2 in the blood exerted on opposite effect. The different responses of the vessels had some similar features in respect to threshold changes of the PCO2 and PO2, to potentiation of effects of both parts of the brain vascular system on increased shifts of the blood gas tension, to greater sensitivity of both parts to PCO2 changes, to effect of the blood gas tension on reactivity of both parts to noradrenaline. The authors suggest a possibility of alterations of the filter-absorption interrelationships in the brain due to different responses of arterial and venous vessels to changes of the blood gas tension.
在麻醉猫中,在血流动力学隔离的脑处于灌注且容积恒定的情况下,高碳酸血症和低氧血症导致脑血管阻力降低以及脑血流量减少,而血液中PCO2降低和PO2升高则产生相反的效果。血管的不同反应在PCO2和PO2的阈值变化、脑循环系统两部分对血气张力增加变化的效应增强、两部分对PCO2变化的更高敏感性、血气张力对两部分对去甲肾上腺素反应性的影响等方面具有一些相似特征。作者提出,由于动脉和静脉血管对血气张力变化的不同反应,脑内滤过 - 吸收相互关系可能发生改变。