不同锥虫物种和亚种中变异特异性表面抗原基因的保守性。

Conservation of a variant-specific surface antigen gene in different trypanosome species and sub-species.

作者信息

Pays E, Lheureux M, Vervoort T, Steinert M

出版信息

Mol Biochem Parasitol. 1981 Dec 31;4(5-6):349-57. doi: 10.1016/0166-6851(81)90066-9.

Abstract

In Trypanosoma brucie brucie, T. b. rhodesiense, T. b. gambiense and T. evansi, the variant-specific antigen (VSA) genes are organized in families of related sequences, one of which is duplicated when expressed. Some of these VSA sequences appear to be conserved in the different species and sub-species: restriction mapping of isotypic genes of AnTat 1.8 VSA (from T. b. brucei) reveals extensive homology in T. b. rhodesiense, T. b. gambiense and T. evansi, although the genetic surrounding differs in each case. By contrast, the AnTat 1.1 sequence (also from T. b. brucei) appears to be absent from T. b. gambiense DNA.

摘要

在布氏布氏锥虫、罗德西亚锥虫、冈比亚锥虫和伊氏锥虫中，变异特异性抗原（VSA）基因以相关序列家族的形式组织，其中一个在表达时会被复制。这些VSA序列中的一些似乎在不同的物种和亚种中是保守的：对AnTat 1.8 VSA（来自布氏布氏锥虫）的同型基因进行限制性图谱分析发现，在罗德西亚锥虫、冈比亚锥虫和伊氏锥虫中存在广泛的同源性，尽管每种情况下的基因环境不同。相比之下，冈比亚锥虫DNA中似乎不存在AnTat 1.1序列（也来自布氏布氏锥虫）。