Merkur'eva R V, Bushinskaia L I, Skvortsova N I, Dolinskaia S I, Shaternikova I S
Vopr Med Khim. 1981 Nov-Dec;27(6):791-4.
Simultaneous effect of benz(a)pyrene and sulphurous gas was accompanied by distinct alteration in metabolism of sialoglycoproteins in liver tissue; at the time N-acetylneuraminic acid was redistributed in liver subcellular organelles (mitochondria, lysosomes and endoplasmic reticulum) as well as cytochromes P-450 and b5 were induced in liver microsomes. The alterations observed appear to play a definite role in manifestation of the unfavourable effect in combined action of the carcinogen and chemical contaminations of environments.
苯并(a)芘和二氧化硫的协同作用伴随着肝脏组织中唾液酸糖蛋白代谢的明显改变；此时，N-乙酰神经氨酸在肝脏亚细胞器（线粒体、溶酶体和内质网）中重新分布，同时肝脏微粒体中的细胞色素P-450和b5也被诱导。所观察到的这些改变似乎在致癌物与环境化学污染物联合作用产生的不利影响的表现中起到了一定作用。
