Elmubarak A K, Sharma J M, Witter R L, Nazerian K, Sanger V L
Avian Dis. 1981 Oct-Dec;25(4):911-26.
Pathogenic Marek's disease (MD) virus (MDV) induced a high incidence of mortality and gross and microscopic lesions in turkey poults. Inoculated turkey poults became persistently viremic with MDV, although the levels of detectable circulating MDV were generally lower in turkeys than in similarly inoculated chickens. The early lytic phase of MD characterized by lymphoid cell destruction and the appearance of viral antigen in lymphoid organ was not as prominent in turkeys as in chickens. Gross MD lesions in turkeys were most prevalent in liver and spleen; peripheral nerves were involved infrequently. MD tumors in turkeys contained cells that reacted with antiserum prepared against chicken MD-tumor-associated surface antigen (MATSA); this result indicated that MDV induced cellular transformation in turkeys and the tumor-associated antigen in chicken and turkeys cross-reacted. Several in vitro-propagating B-cell lines were developed from the turkey lymphomas. As in chickens, MD in turkeys also resulted in immunodepression. Circulating lymphocytes from turkeys that eventually died of MD or had gross tumors at the end of the experiment were deficient in mitogenic response to Concanavalin A.
致病性马立克氏病（MD）病毒（MDV）可导致火鸡雏鸡出现高死亡率以及明显的大体病变和微观病变。接种后的火鸡雏鸡会持续感染MDV病毒血症，不过火鸡体内可检测到的循环MDV水平通常低于同样接种的鸡。MD早期的溶细胞阶段以淋巴样细胞破坏以及淋巴器官中出现病毒抗原为特征，这一阶段在火鸡中不如在鸡中明显。火鸡的MD大体病变在肝脏和脾脏中最为常见；外周神经很少受累。火鸡的MD肿瘤含有与针对鸡MD肿瘤相关表面抗原（MATSA）制备的抗血清发生反应的细胞；这一结果表明MDV可诱导火鸡发生细胞转化，并且鸡和火鸡的肿瘤相关抗原会发生交叉反应。从火鸡淋巴瘤中培养出了几种体外增殖的B细胞系。与鸡一样，火鸡的MD也会导致免疫抑制。在实验结束时最终死于MD或出现明显肿瘤的火鸡的循环淋巴细胞对刀豆球蛋白A的促有丝分裂反应存在缺陷。
