Hunter J E
J Nutr. 1978 Mar;108(3):497-505. doi: 10.1093/jn/108.3.497.
The present studies were conducted to determine the relationships between iron status and ferritin levels in plasma, liver, and spleen of rats. Rats were fed either iron-adequate or iron-deficient purified diets, and measurements of hemoglobin and plasma and tissue ferritin levels were made at various times during iron depletion and iron repletion. Although mean plasma ferritin concentrations of iron-deficient rats were directionally less than those of iron-adequate rats, these differences were not statistically significant due to high variability among similarly treated animals. During iron repletion plasma ferritin concentrations again were so variable that no significant effect of iron repletion on plasma ferritin concentrations was observed. On the other hand, liver and spleen ferritin concentrations of similarly treated rats were much less variable. Ferritin liver and spleen stores decreased more rapidly than hemoglobin during iron deficiency and were restored more slowly than hemoglobin during iron repletion. There was no evidence of correlation between liver and plasma ferritin concentration. Because of the variable responses of plasma ferritin concentration to iron depletion and repletion and the lack of relationship between plasma and liver ferritin concentrations, it is concluded that plasma ferritin concentration is not a good indicator of iron status in rats.
开展本研究以确定大鼠血浆、肝脏和脾脏中铁状态与铁蛋白水平之间的关系。给大鼠喂食铁充足或铁缺乏的纯化日粮，并在缺铁和补铁的不同时间测量血红蛋白以及血浆和组织铁蛋白水平。尽管缺铁大鼠的平均血浆铁蛋白浓度在趋势上低于铁充足大鼠，但由于相同处理动物之间的高变异性，这些差异无统计学意义。在补铁期间，血浆铁蛋白浓度再次变化很大，以至于未观察到补铁对血浆铁蛋白浓度有显著影响。另一方面，相同处理大鼠的肝脏和脾脏铁蛋白浓度变异性小得多。在缺铁期间，肝脏和脾脏铁蛋白储存量比血红蛋白下降得更快，而在补铁期间，其恢复比血红蛋白更慢。没有证据表明肝脏和血浆铁蛋白浓度之间存在相关性。由于血浆铁蛋白浓度对缺铁和补铁的反应多变，且血浆与肝脏铁蛋白浓度之间缺乏关联，因此得出结论，血浆铁蛋白浓度不是大鼠铁状态的良好指标。
