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在味觉厌恶学习实验中作为辨别性刺激的药物状态。

Drug states as discriminative stimuli in a flavor-aversion learning experiment.

作者信息

Revusky S, Coombes S, Pohl R W

出版信息

J Comp Physiol Psychol. 1982 Apr;96(2):200-11. doi: 10.1037/h0077870.

DOI:10.1037/h0077870
PMID:6279713
Abstract

Injection of poison into rats after they drank in the presence of stimulus compounds of a drug state and a flavor resulted in little stimulus control by the drug state. In Experiment 1, half of the rats were poisoned after drinking salt water while stimulated with amphetamine and after drinking sugar water while sedated with pentobarbital, but they were not poisoned after salt-pentobarbital or sugar-amphetamine combinations. The other half were subjected to counterbalanced procedures. In abstract language, poisoning occurred after AX and BY stimulus combinations but did not occur after AY and BX combinations. In Experiment 2A, rats were poisoned only after consuming a particular flavored solution (salt or vinegar) in a particular state (pentobarbital or undrugged); that is, if AX was poisoned, BX, BY, and AY were experienced without poisoning. There was complete counterbalancing of flavors and drug states. Experiment 2B was similar except that amphetamine was used instead of pentobarbital. In both experiments, there was some discrimination learning based on the drug state, gut it was extremely weak.

摘要

在大鼠饮用含有药物状态和味道的刺激化合物的液体后给它们注射毒药,结果药物状态对其刺激控制作用很小。在实验1中,一半的大鼠在饮用盐水时受到苯丙胺刺激后被注射毒药,在饮用糖水时受到戊巴比妥镇静后也被注射毒药,但在饮用盐水-戊巴比妥或糖水-苯丙胺组合后未被注射毒药。另一半大鼠接受了平衡程序。用抽象的语言来说,在AX和BY刺激组合后发生了中毒,但在AY和BX组合后未发生中毒。在实验2A中,大鼠仅在处于特定状态(戊巴比妥或未用药)下饮用特定味道的溶液(盐水或醋)后被注射毒药;也就是说,如果AX被注射毒药,那么BX、BY和AY在未中毒的情况下经历。味道和药物状态进行了完全平衡。实验2B与之类似,只是用苯丙胺代替了戊巴比妥。在两个实验中,都有基于药物状态的一些辨别学习,但非常微弱。

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Drug states as discriminative stimuli in a flavor-aversion learning experiment.在味觉厌恶学习实验中作为辨别性刺激的药物状态。
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Psychopharmacology (Berl). 1988;96(3):400-7. doi: 10.1007/BF00216070.
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Trends in drug discrimination research analysed with a cross-indexed bibliography, 1982-1983.1982 - 1983年,利用交叉索引书目分析药物辨别研究的趋势。
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