Pinon G, Quentin R, Boscq G, Berger C, Lansac J
Nouv Presse Med. 1982 Mar 20;11(13):999-1002.
The three cases reported were diagnosed at the time of contamination by direct examination and culture, at birth, of placental tissue, gastric fluid and peripheral specimens. The culture media included a chocolate agar medium favourable to the growth of H. influenzae. One of the isolates was beta-lactamase producer and therefore resistant to the group A penicillins usually prescribed. Determination of the M.I.C.s of eight antibiotics showed that cefotaxime constitutes, for the time being, a suitable alternative to penicillins against such strains. Early detection of H. influenzae perinatal infections make it possible to treat neonates before complications develop. Among the 19 cases published, there were 4 cases of meningitis, 8 cases of septicaemia and 1 case of arthritis.
报告的这三例病例是在污染时通过对胎盘组织、胃液和外周标本进行直接检查和培养(在出生时)确诊的。培养基包括有利于流感嗜血杆菌生长的巧克力琼脂培养基。其中一株分离菌产β-内酰胺酶,因此对通常开具的A组青霉素耐药。对八种抗生素的最低抑菌浓度(MIC)测定表明,头孢噻肟目前是针对此类菌株替代青霉素的合适选择。围产期流感嗜血杆菌感染的早期检测使得在并发症发生前治疗新生儿成为可能。在已发表的19例病例中,有4例脑膜炎、8例败血症和1例关节炎。