淡嗜酸性包涵体，类似肝细胞癌细胞的毛玻璃样外观。

Pale eosinophilic inclusions simulating ground-glass appearance of cells of hepatocellular carcinoma.

作者信息

Nakanuma Y, Kono N, Ohta G, Shirasaki S, Takeshita H, Watanabe K, Tsuda S, Yoshizawa H

出版信息

Acta Pathol Jpn. 1982 Jan;32(1):71-81. doi: 10.1111/j.1440-1827.1982.tb02028.x.

DOI:10.1111/j.1440-1827.1982.tb02028.x

Abstract

Pale eosinophilic inclusions simulating ground-glass appearance were observed in cells of hepatocellular carcinoma. They were round or elliptical in shape, and their size was about 14 micrometers in diameter. Light eosinophilia and fine granulation with homogeneous appearance were delineated from other cellular materials. They were negative for HBsAg, blood plasma proteins including alpha 1-antitrypsin, and alpha-fetoprotein by immunohistochemical stainings. Ultrastructurally, they were well-demarcated and consisted of homogeneous finely granular matrix. Histological, histochemical and ultrastructural features were different from several intracellular inclusions hitherto reported on hepatocellular carcinoma. These changes may represent a deposition of secretory proteinous materials in cells of hepatocellular carcinoma, but their chemical and antigenetical content could not be identified.

摘要

在肝细胞癌的细胞中观察到类似毛玻璃样外观的淡嗜酸性包涵体。它们呈圆形或椭圆形，直径约14微米。其淡嗜酸性和具有均匀外观的细颗粒状与其他细胞物质不同。免疫组织化学染色显示，它们对乙肝表面抗原、包括α1抗胰蛋白酶在内的血浆蛋白以及甲胎蛋白均呈阴性。超微结构上，它们界限分明，由均匀的细颗粒基质组成。组织学、组织化学和超微结构特征与迄今报道的几种肝细胞癌的细胞内包涵体不同。这些变化可能代表肝细胞癌细胞中分泌性蛋白质物质的沉积，但其化学和抗原成分尚无法确定。