Rømer F K
Acta Med Scand. 1982;211(1-2):31-3. doi: 10.1111/j.0954-6820.1982.tb01898.x.
Serum angiotensin-converting enzyme (SACE) was elevated (mean +/- S.D. 55.2 +/- 19.8 U/ml) in 11 patients with hypercalcaemia due to sarcoidosis, whereas it was within the normal limits ((20.0 +/- 5.2 U/ml) in 23 patients with other hypercalcaemic conditions. Among these, 16 had primary hyperparathyroidism and a SACE level of 18.6 +/- 4.7 U/ml, significantly lower than in healthy controls (24.4 +/- 6.2 U/ml). In 7 patients with hypercalcaemia due to malignancies or prolonged immobilization SACE was 21.8 +/- 5.9 U/ml. A weakly positive correlation was found between SACE and S-calcium in hypercalcaemic sarcoidosis patients but not in the other patients or in a control group of 144 consecutive sarcoidosis patients. sarcoidosis with hypercalcaemia seems to be associated with a very high prevalence of elevated SACE. Especially when sarcoidosis is suspected to be the cause of hypercalcaemia, SACE measurement may be useful as a rapid diagnostic guide.
11例结节病所致高钙血症患者的血清血管紧张素转换酶（SACE）升高（均值±标准差为55.2±19.8 U/ml），而23例其他高钙血症患者的SACE在正常范围内（20.0±5.2 U/ml）。其中，16例原发性甲状旁腺功能亢进患者的SACE水平为18.6±4.7 U/ml，显著低于健康对照者（24.4±6.2 U/ml）。7例恶性肿瘤或长期制动所致高钙血症患者的SACE为21.8±5.9 U/ml。在高钙血症结节病患者中，SACE与血清钙呈弱正相关，但在其他患者或144例连续结节病患者的对照组中未发现这种相关性。高钙血症结节病似乎与SACE升高的高患病率相关。特别是当怀疑结节病是高钙血症的病因时，检测SACE可能有助于快速诊断。
