Lufkin E G, DeRemee R A, Rohrbach M S
Mayo Clin Proc. 1983 Jul;58(7):447-51.
Serum angiotensin-converting enzyme (SACE) activity is usually elevated in sarcoidosis, and this raises the possibility that SACE may be a useful diagnostic tool in distinguishing sarcoidosis from other hypercalcemic disorders. We therefore measured SACE in a large number of patients with various granulomatous, metabolic, and hypercalcemic disorders to determine its predictive value. We found elevated SACE activity in 4 of 35 surgically proven cases of primary hyperparathyroidism and in 3 of 13 patients with oncogenic hypercalcemia. In six patients with sarcoidosis and hypercalcemia, SACE activity was elevated; corticosteroid therapy lowered both the serum calcium and SACE levels to normal. We conclude that SACE activity is not a specific test for the differential diagnosis of hypercalcemia but that it remains useful as a chemical marker of successful treatment of sarcoidosis.
血清血管紧张素转换酶（SACE）活性在结节病中通常会升高，这增加了SACE可能成为区分结节病与其他高钙血症疾病的有用诊断工具的可能性。因此，我们对大量患有各种肉芽肿性、代谢性和高钙血症疾病的患者进行了SACE测量，以确定其预测价值。我们发现，在35例经手术证实的原发性甲状旁腺功能亢进病例中有4例SACE活性升高，在13例肿瘤性高钙血症患者中有3例升高。在6例结节病合并高钙血症患者中，SACE活性升高；皮质类固醇治疗使血清钙和SACE水平均降至正常。我们得出结论，SACE活性不是高钙血症鉴别诊断的特异性检测方法，但它仍然是结节病成功治疗的有用化学标志物。
