Aizawa T, Greer M A
Endocrinology. 1982 May;110(5):1693-700. doi: 10.1210/endo-110-5-1693.
Anterolateral hypothalamic deafferentiation was made in rats to explore the importance of the neural pathways through the lateral retrochiasmatic area (RCAL) in the regulation of ACTH and TSH secretion. In rats with complete bilateral RCAL transection, pituitary-adrenal function was altered in the following respects compared to sham-operated controls. 1) Basal plasma ACTH, corticosterone (B), and adrenal weight were depressed. 2) Plasma ACTH and B elevation in response to 3-min ether inhalation were markedly decreased or abolished. 3) Insulin-induced hypoglycemia produced no or little plasma B elevation. 4) Lysine-vasopressin was significantly less effective in inducing pituitary-adrenal activation. Reductions in plasma ACTH and B concentrations and adrenal weight were correlated with the completeness of the RCAL transection. The plasma TSH concentration was lower in the deafferented rats than in the controls regardless of the completeness of the cut at the RCAL, indicating that the neural pathways traversing this area do not possess a critical importance for the regulation of TSH if the rest of the hypothalamus is deafferented anterolaterally. We conclude that intact neural connections between the medial basal hypothalamus and the central nervous system at the RCAL are essential for the maintenance of normal hypothalamic-pituitary-adrenal function.
对大鼠进行下丘脑前外侧去传入神经支配，以探究通过视交叉后外侧区（RCAL）的神经通路在促肾上腺皮质激素（ACTH）和促甲状腺激素（TSH）分泌调节中的重要性。与假手术对照组相比，在双侧RCAL完全横断的大鼠中，垂体-肾上腺功能在以下方面发生了改变。1）基础血浆ACTH、皮质酮（B）和肾上腺重量降低。2）吸入乙醚3分钟后血浆ACTH和B的升高明显降低或消失。3）胰岛素诱导的低血糖未引起或仅引起少量血浆B升高。4）赖氨酸加压素诱导垂体-肾上腺激活的效果明显较差。血浆ACTH和B浓度以及肾上腺重量的降低与RCAL横断的完整性相关。无论RCAL处切断的完整性如何，去传入神经支配的大鼠血浆TSH浓度均低于对照组，这表明如果下丘脑其余部分从前外侧去传入神经支配，那么穿过该区域的神经通路对TSH的调节并不具有关键重要性。我们得出结论，下丘脑内侧基底部与RCAL处中枢神经系统之间完整的神经连接对于维持正常的下丘脑-垂体-肾上腺功能至关重要。
