A significant role of proximity of HVJ-antigen in the generation of tumor immunity.

According to the blocking test for proximity of cell surface antigens, L1210 leukemia-associated antigen was not linked to molecules carrying H-2d antigen or murine leukemia virus-associated antigen, but there was a close association between HVJ-associated antigen and L1210 leukemia-associated antigen on the surface membrane of HVJ-pi-infected L1210 leukemia cells. Once L1210 leukemia cells were infected with HVJ-pi, their adsorptive power was found to be greater than that of uninfected cells by quantitative absorption analysis. These phenomena may lead to a better recognition by the host of L1210 leukemia-associated antigen, followed by generation of tumor immunity.