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复合转座子Tn2672的出现与特性：多重耐药转座子的进化

Occurrence and properties of composite transposon Tn2672: evolution of multiple drug resistance transposons.

作者信息

Hänni C, Meyer J, Iida S, Arber W

出版信息

J Bacteriol. 1982 Jun;150(3):1266-73. doi: 10.1128/jb.150.3.1266-1273.1982.

DOI:10.1128/jb.150.3.1266-1273.1982
PMID:6281241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC216349/
Abstract

We found Tn2671 (the 23-kb long IS1-flanked r-determinant of NR1-Basel) inserted into the ampicillin resistance gene bla of the Tn3-related transposon Tn902. The resulting 28-kilobase-long composite transposon Tn2672 (= Tn902 bla::Tn2671) is stable, and it translocates as a unit into various loci including IS1 of the resistance transfer factor of R100-1. These results are discussed with respect to the evolution of R plasmids providing multiple drug resistance.

摘要

我们发现Tn2671（NR1 - 巴塞尔的23kb长的侧翼为IS1的r - 决定簇）插入到了与Tn3相关的转座子Tn902的氨苄青霉素抗性基因bla中。由此产生的28kb长的复合转座子Tn2672（= Tn902 bla::Tn2671）是稳定的，并且它作为一个整体转移到包括R100 - 1抗性转移因子的IS1在内的各种位点。结合提供多重耐药性的R质粒的进化对这些结果进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd5/216349/c7e3d50e4cc2/jbacter00259-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd5/216349/b5be5ef65b6e/jbacter00259-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd5/216349/c7e3d50e4cc2/jbacter00259-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd5/216349/b5be5ef65b6e/jbacter00259-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdd5/216349/c7e3d50e4cc2/jbacter00259-0283-a.jpg

相似文献

1
Occurrence and properties of composite transposon Tn2672: evolution of multiple drug resistance transposons.复合转座子Tn2672的出现与特性：多重耐药转座子的进化
J Bacteriol. 1982 Jun;150(3):1266-73. doi: 10.1128/jb.150.3.1266-1273.1982.
2
Reversion of a truncated gene for ampicillin resistance by genetic rearrangements in Escherichia coli K12.通过大肠杆菌K12中的基因重排使氨苄青霉素抗性截短基因回复突变。
Mol Gen Genet. 1985;201(2):174-7. doi: 10.1007/BF00425656.
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Is the IS1-flanked r-determinant of the R plasmid NR1 a transposon?R质粒NR1中IS1侧翼的r决定子是转座子吗？
J Gen Microbiol. 1981 Oct;126(2):413-25. doi: 10.1099/00221287-126-2-413.
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DNA inversion mediated by the r-determinant of plasmid NR1: evidence for the intramolecular replicative transposition of a 23 kb IS1-flanked transposon?
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[Cis-active function of plasmid R 57 resolving co-integrates formed during transposition of ISI-elements].[质粒R57在IS1元件转座过程中形成的共整合体的顺式活性功能]
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Complex multiple antibiotic and mercury resistance region derived from the r-det of NR1 (R100).源自NR1（R100）的r-det的复杂多重抗生素和汞抗性区域。
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Transposon Tn21, flagship of the floating genome.转座子Tn21，流动基因组的标志。

本文引用的文献

1
Is the IS1-flanked r-determinant of the R plasmid NR1 a transposon?R质粒NR1中IS1侧翼的r决定子是转座子吗？
J Gen Microbiol. 1981 Oct;126(2):413-25. doi: 10.1099/00221287-126-2-413.
2
Cointegrates between bacteriophage P1 DNA and plasmid pBR322 derivatives suggest molecular mechanisms for P1-mediated transduction of small plasmids.噬菌体P1 DNA与质粒pBR322衍生物之间的共整合体揭示了P1介导的小质粒转导的分子机制。
Mol Gen Genet. 1981;184(1):1-10. doi: 10.1007/BF00271186.
3
Genesis and natural history of IS-mediated transposons.插入序列介导的转座子的起源与自然史。
Microbiol Mol Biol Rev. 1999 Sep;63(3):507-22. doi: 10.1128/MMBR.63.3.507-522.1999.
4
Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical, and genetic analyses.微生物对汞及有机汞化合物的抗性与解毒机制：生理学、生物化学及遗传学分析
Microbiol Rev. 1984 Jun;48(2):95-124. doi: 10.1128/mr.48.2.95-124.1984.
5
Phenotypic reversion of an IS1-mediated deletion mutation: a combined role for point mutations and deletions in transposon evolution.IS1介导的缺失突变的表型回复：点突变和缺失在转座子进化中的联合作用。
EMBO J. 1982;1(6):755-9. doi: 10.1002/j.1460-2075.1982.tb01242.x.
6
Nucleotide sequence of the prokaryotic mobile genetic element IS30.原核生物移动遗传元件IS30的核苷酸序列。
EMBO J. 1984 Sep;3(9):2145-9. doi: 10.1002/j.1460-2075.1984.tb02104.x.
7
Genetic and physical map of plasmid NR1: comparison with other IncFII antibiotic resistance plasmids.质粒NR1的遗传图谱和物理图谱：与其他IncFII型抗生素抗性质粒的比较。
Microbiol Rev. 1988 Dec;52(4):433-51. doi: 10.1128/mr.52.4.433-451.1988.
8
DNA inversion mediated by the r-determinant of plasmid NR1: evidence for the intramolecular replicative transposition of a 23 kb IS1-flanked transposon?
Mol Gen Genet. 1986 Dec;205(3):572-4. doi: 10.1007/BF00338102.
9
Transposonlike elements in Caedibacter taeniospiralis.螺旋体尾菌中的类转座子元件。
J Bacteriol. 1986 Apr;166(1):349-52. doi: 10.1128/jb.166.1.349-352.1986.
10
Reversion of a truncated gene for ampicillin resistance by genetic rearrangements in Escherichia coli K12.通过大肠杆菌K12中的基因重排使氨苄青霉素抗性截短基因回复突变。
Mol Gen Genet. 1985;201(2):174-7. doi: 10.1007/BF00425656.
Cold Spring Harb Symp Quant Biol. 1981;45 Pt 1:27-43. doi: 10.1101/sqb.1981.045.01.006.
4
The structure of R1drd19: a revised physical map of the plasmid.R1drd19的结构：该质粒的修订物理图谱。
Mol Gen Genet. 1981;181(2):183-91. doi: 10.1007/BF00268425.
5
Genetic organization of transposon Tn10.转座子Tn10的基因组织
Cell. 1981 Jan;23(1):201-13. doi: 10.1016/0092-8674(81)90285-3.
6
Isolation of an IS1 flanked kanamycin resistance transposon from R1drd19.从R1drd19中分离出一个侧翼为IS1的卡那霉素抗性转座子。
Mol Gen Genet. 1980;180(1):123-7. doi: 10.1007/BF00267360.
7
Deletions and an inversion induced by a resident IS1 of the lactose transposon Tn951.乳糖转座子Tn951的一个常驻IS1诱导的缺失和倒位。
Mol Gen Genet. 1980;178(2):367-74. doi: 10.1007/BF00270486.
8
Transposition of IS1-lambdaBIO-IS1 from a bacteriophage lambda derivative carrying the IS1-cat-IS1 transposon (Tn9).IS1-lambdaBIO-IS1 从携带 IS1-cat-IS1 转座子（Tn9）的噬菌体 λ 衍生物上发生转座。
Mol Gen Genet. 1980 Apr;178(1):111-20. doi: 10.1007/BF00267219.
9
Genetic evidence for absence of transposition functions from the internal part of Tn981 a relative of Tn9.Tn981（Tn9的一个亲缘基因）内部缺失转座功能的遗传学证据。
Mol Gen Genet. 1980;177(4):667-74. doi: 10.1007/BF00272678.
10
On the role of IS1 in the formation of hybrids between the bacteriophage P1 and the R plasmid NR1.关于IS1在噬菌体P1与R质粒NR1之间杂种形成中的作用。
Mol Gen Genet. 1980 Jan;177(2):261-70. doi: 10.1007/BF00267437.