Antholine W, Taketa F
J Inorg Biochem. 1982 Apr;16(2):145-54. doi: 10.1016/s0162-0134(00)80222-6.
The antitumor agent 2-formylpyridine monothiosemicarbazonato copper(II) forms adducts with sulfur and nitrogen donor atoms from cat hemoglobin but only nitrogen donor atoms from human hemoglobin. Improved resolution of the mI = 1/2 lines in the g parallel region at S-band not only confirms the number of nitrogen donor atoms in the square planar configuration but provides evidence for strong coupling from a proton. Adduct formation results in an increase in the oxygen affinity of hemoglobin. Thus, it is suggested that allosteric enzyme inhibition may be a mechanism for the action of this agent.
抗肿瘤剂2-甲酰基吡啶单硫代氨基脲合铜（II）与猫血红蛋白中的硫和氮供体原子形成加合物，但仅与人血红蛋白中的氮供体原子形成加合物。在S波段g平行区域中mI = 1/2谱线分辨率的提高不仅证实了平面正方形构型中氮供体原子的数量，还提供了来自质子的强耦合的证据。加合物的形成导致血红蛋白的氧亲和力增加。因此，有人提出变构酶抑制可能是该药物作用的一种机制。
