Fenner F
Lab Anim Sci. 1981 Oct;31(5 Pt 2):553-9.
Mousepox is an orthopoxvirus infection of mice that was discovered in laboratory mice in England in 1930. Depending upon mouse genotype, it may produce a severe disease with acute hepatitis and high mortality, a generalized rash in animals that survive longer, or a trivial inapparent infection. It has long been enzootic in breeding stocks of mice in Europe, Japan, and China but not in North America and Australia. However, it has been imported into the USA on several occasions, sometimes causing severe epizootics. It may contaminate or replace various viruses that are passaged in mice and may be transferred between mouse stocks in intact mice or in mouse tumors or tissues. Vaccination with vaccinia virus provides protection and has been used to eradicate virus from mouse colonies. Depopulation and sterilization of infected animal quarters my be required.
鼠痘是小鼠的一种正痘病毒感染，于1930年在英国的实验小鼠中被发现。根据小鼠基因型的不同，它可能引发伴有急性肝炎和高死亡率的严重疾病、在存活时间较长的动物身上出现全身性皮疹，或者是轻微的隐性感染。长期以来，它在欧洲、日本和中国的小鼠繁殖种群中呈地方流行性，但在北美和澳大利亚并非如此。然而，它曾多次被引入美国，有时会引发严重的动物流行病。它可能污染或取代在小鼠中传代的各种病毒，并可能在完整小鼠、小鼠肿瘤或组织中的小鼠种群之间传播。用痘苗病毒接种可提供保护，并且已被用于从小鼠群体中根除该病毒。可能需要对受感染的动物饲养区进行种群扑杀和消毒。
