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禽肉瘤病毒Y73的基因组序列及其转化基因产物与劳氏肉瘤病毒转化基因产物的结构相似性。

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus.

作者信息

Kitamura N, Kitamura A, Toyoshima K, Hirayama Y, Yoshida M

出版信息

Nature. 1982 May 20;297(5863):205-8. doi: 10.1038/297205a0.

DOI:10.1038/297205a0
PMID:6281656
Abstract

From the complete nucleotide sequence of the genome of the avian sarcoma virus Y73, we have predicted amino acid sequence of p90 gag-yes, the product of the transforming gene. Contrary to previous evidence from molecular hybridization studies p90 gag-yes was found to have much homology with the transforming gene product p60 src of Rous sarcoma virus, suggesting that the cellular counterparts of the two (c-yes and c-src) originated from a common prototype sequence.

摘要

从禽肉瘤病毒Y73基因组的完整核苷酸序列中,我们预测了转化基因产物p90 gag-yes的氨基酸序列。与先前分子杂交研究的证据相反,发现p90 gag-yes与劳氏肉瘤病毒的转化基因产物p60 src有很多同源性,这表明两者的细胞对应物(c-yes和c-src)起源于一个共同的原型序列。

相似文献

1
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus.禽肉瘤病毒Y73的基因组序列及其转化基因产物与劳氏肉瘤病毒转化基因产物的结构相似性。
Nature. 1982 May 20;297(5863):205-8. doi: 10.1038/297205a0.
2
Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.禽肉瘤病毒Y73的特性:一种独特的转化基因及其产物,一种具有蛋白激酶活性的磷酸化多蛋白。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6199-203. doi: 10.1073/pnas.77.10.6199.
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Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog.恢复性禽肉瘤病毒的病毒转化基因(src)与其细胞同源基因的比较。
Mol Cell Biol. 1981 Nov;1(11):1024-37. doi: 10.1128/mcb.1.11.1024-1037.1981.
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Genome structure of avian sarcoma virus Y73 and unique sequence coding for polyprotein p90.禽肉瘤病毒Y73的基因组结构及编码多聚蛋白p90的独特序列
J Virol. 1981 May;38(2):430-7. doi: 10.1128/JVI.38.2.430-437.1981.
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Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.禽肉瘤病毒癌基因(src)的核苷酸序列及基因产物的推测氨基酸序列。
Nature. 1980 Sep 18;287(5779):198-203. doi: 10.1038/287198a0.
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Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.禽肉瘤病毒UR2编码一种与独特蛋白激酶活性相关的转化蛋白。
J Virol. 1982 Apr;42(1):228-36. doi: 10.1128/JVI.42.1.228-236.1982.
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Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes.未感染的禽类细胞含有结构上不相关的病毒肉瘤基因的祖细胞。
Nature. 1980 Oct 16;287(5783):653-4. doi: 10.1038/287653a0.
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[Identification and the origin of oncogenes, with special reference to sarcoma virus Y73].[癌基因的鉴定及其起源,特别提及肉瘤病毒Y73]
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Oncogene and its production of an avian sarcoma virus Y73.癌基因及其在禽肉瘤病毒Y73中的产生。
Princess Takamatsu Symp. 1982;12:275-83.

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