Neuronal localization of the tyrosine-specific protein kinase p62c-yes in rat basal ganglia.

The cellular localization of the tyrosine-specific protein kinase p62c-yes, the product of the proto-oncogene c-yes, has been examined in the striatonigral neurons which interconnect the rat neostriatum and substantia nigra. Although p62c-yes was more enriched in the neostriatum than in the substantia nigra, excitotoxin-induced necrosis of nerve cells in the neostriatum led to 50-60% decreases of p62c-yes both in the lesioned neostriatum and in the ipsilateral substantia nigra. Hence, the p62c-yes tyrosine kinase is present both in the cell body region and in the axonal and nerve terminal region of the striatonigral neurons. This localization indicates that the enzyme may be involved in both presynaptic and postsynaptic functions in mammalian forebrain neurons.