Walaas S I, Zhao Y H, Sudol M
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021.
Neurochem Res. 1993 Jan;18(1):43-6. doi: 10.1007/BF00966921.
The cellular localization of the tyrosine-specific protein kinase p62c-yes, the product of the proto-oncogene c-yes, has been examined in the striatonigral neurons which interconnect the rat neostriatum and substantia nigra. Although p62c-yes was more enriched in the neostriatum than in the substantia nigra, excitotoxin-induced necrosis of nerve cells in the neostriatum led to 50-60% decreases of p62c-yes both in the lesioned neostriatum and in the ipsilateral substantia nigra. Hence, the p62c-yes tyrosine kinase is present both in the cell body region and in the axonal and nerve terminal region of the striatonigral neurons. This localization indicates that the enzyme may be involved in both presynaptic and postsynaptic functions in mammalian forebrain neurons.
原癌基因c-yes的产物——酪氨酸特异性蛋白激酶p62c-yes，在连接大鼠新纹状体和黑质的纹状体黑质神经元中的细胞定位已被研究。尽管p62c-yes在新纹状体中的富集程度高于黑质，但新纹状体内神经细胞的兴奋性毒素诱导坏死导致病变新纹状体和同侧黑质中的p62c-yes均减少50%-60%。因此，p62c-yes酪氨酸激酶存在于纹状体黑质神经元的细胞体区域以及轴突和神经末梢区域。这种定位表明该酶可能参与哺乳动物前脑神经元的突触前和突触后功能。
