Le Quesne P M, Maxwell I C
Neurotoxicology. 1981 Dec;2(4):675-85.
Regional intravenous injections of different amounts (1-3 mg) of edrophonium were given to the hand of a healthy subject. The earliest change was a small negative deflection occurring at the end of the muscle response evoked by nerve stimulation, due to repetitive activity. It did not occur after a second stimulus at 30 ms or immediately after 10 s maximum voluntary contraction. Repetitive stimulation at 0.5 Hz reduced the repetitive activity. With a higher dose of edrophonium the response to a second shock (M2) at 30 ms was reduced in amplitude, but M2 at 80 ms was unaffected. An even larger dose caused depression of M2 at 80 ms also and a decremental response to 50 Hz stimulation. The amplitude of the response to a single shock was unchanged throughout.
向一名健康受试者的手部进行不同剂量（1 - 3毫克）的依酚氯铵区域静脉注射。最早出现的变化是在神经刺激诱发的肌肉反应结束时出现一个小的负向偏转，这是由于重复活动所致。在30毫秒时给予第二次刺激后或在最大自主收缩10秒后立即不会出现这种情况。以0.5赫兹进行重复刺激可降低重复活动。使用更高剂量的依酚氯铵时，30毫秒时对第二次电击（M2）的反应幅度减小，但80毫秒时的M2不受影响。甚至更大的剂量也会导致80毫秒时的M2也受到抑制，并且对50赫兹刺激出现递减反应。对单次电击的反应幅度在整个过程中保持不变。
