敌百虫对神经肌肉传递的作用。

Effect of metrifonate on neuromuscular transmission.

作者信息

Le Quesne P M, Maxwell I C

出版信息

Acta Pharmacol Toxicol (Copenh). 1981;49 Suppl 5:99-104. doi: 10.1111/j.1600-0773.1981.tb03258.x.

DOI:10.1111/j.1600-0773.1981.tb03258.x

Abstract

The least detectable effect of acute cholinesterase inhibition (produced by edrophonium) in a normal subject is described. It consists of repetitive activity following the muscle response to a single nerve stimulus. Repetitive activity does not follow a second response at an interval of 30 msec. or 80 msec. There is no change in amplitude of the response to a single stimulus; nor to a second stimulus with the smallest dose of edrophonium. With higher doses of edrophonium the amplitude of the second response is reduced. 55 children were studied during treatment of urinary schistosomiasis with metrifonate (3 doses at 2 weekly intervals). No change in evoked muscle action potential amplitude attributable to treatment was detected. 3 children developed some repetitive activity 6 hours after their third dose, when erythrocyte cholinesterase inhibition was approximately 50%.

摘要

描述了正常受试者中急性胆碱酯酶抑制（由依酚氯铵产生）的最小可检测效应。它表现为肌肉对单个神经刺激产生反应后的重复活动。重复活动在30毫秒或80毫秒的间隔后不会跟随第二次反应。对单个刺激的反应幅度没有变化；对使用最小剂量依酚氯铵的第二次刺激的反应幅度也没有变化。使用更高剂量的依酚氯铵时，第二次反应的幅度会降低。在使用敌百虫（每2周3剂）治疗泌尿血吸虫病期间，对55名儿童进行了研究。未检测到因治疗导致的诱发性肌肉动作电位幅度变化。3名儿童在第三次服药6小时后出现了一些重复活动，此时红细胞胆碱酯酶抑制率约为50%。