鸟氨酸转氨酶与鸟氨酸的反应。
The reaction of ornithine aminotransferase with ornithine.
作者信息
Williams J A, Bridge G, Fowler L J, John R A
出版信息
Biochem J. 1982 Jan 1;201(1):221-5. doi: 10.1042/bj2010221.
Abstract
Rat liver ornithine aminotransferase is found to exchange the pro-S hydrogen on the delta-carbon atom of ornithine exclusively, thus showing that the mammalian enzyme transfers the delta-amino group and not the alpha-amino group as has been demonstrated with the plant enzyme [Mestichelli, Gupta & Spenser (1979) J. Biol. Chem. 254, 640-647]. The enzyme also transfers the alpha-amino group of glutamate and the kinetics of the half reactions between the enzyme and both amino acids are compared. Rate and dissociation constants for both reactions are determined.
摘要
已发现大鼠肝脏鸟氨酸转氨酶仅交换鸟氨酸δ碳原子上的前-S氢，从而表明该哺乳动物酶转移的是δ-氨基而非α-氨基，正如植物酶所证实的那样[梅斯蒂凯利、古普塔和斯彭斯（1979年）《生物化学杂志》254卷，640 - 647页]。该酶还转移谷氨酸的α-氨基，并比较了酶与这两种氨基酸之间半反应的动力学。测定了两个反应的速率和离解常数。
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