Wroblewski J T, Blaker W D, Meek J L
Brain Res. 1985 Mar 11;329(1-2):161-8. doi: 10.1016/0006-8993(85)90521-9.
Local injections of L-canaline into the septum produce a rapid and almost complete inhibition of ornithine aminotransferase activity followed by a decrease in glutamate content in this region. The time-course of canaline action shows the existence of two glutamate pools with different sizes and half-life values. Surgical lesions of the hippocampal-septal glutamatergic pathway affected the site and kinetics of the small pool of glutamate in the septum, suggesting the participation of ornithine aminotransferase in the synthesis of this pool. This indicates a possible role of ornithine as a precursor of the transmitter glutamate. The localization of ornithine aminotransferase does not seem, however, to be specific for the nerve-terminal compartment. The data obtained allow estimation of the turnover rate of the specific pool of neurotransmitter glutamate.
向中隔局部注射L-刀豆氨酸会迅速且几乎完全抑制鸟氨酸转氨酶活性，随后该区域的谷氨酸含量会降低。刀豆氨酸作用的时间进程表明存在两个大小和半衰期值不同的谷氨酸池。海马-中隔谷氨酸能通路的手术损伤影响了中隔中谷氨酸小池的位置和动力学，这表明鸟氨酸转氨酶参与了该池的合成。这表明鸟氨酸可能作为神经递质谷氨酸的前体发挥作用。然而，鸟氨酸转氨酶的定位似乎并非神经末梢区所特有。所获得的数据有助于估算神经递质谷氨酸特定池的周转率。
