Surewicz W K
Biochem Pharmacol. 1982 Mar 1;31(5):691-4. doi: 10.1016/0006-2952(82)90451-8.
The effect of propranolol on the structure of human erythrocyte membranes was studied using a spin labeling technique. Changes in electron spin resonance spectra of spin labeled membrane proteins were detected at concentration of the drug corresponding to its antihemolytic effect on intact erythrocytes. The character of spectral changes suggests that propranolol-induced alterations in organization of membrane proteins are connected mainly with perturbation of protein sites located on membrane surface. Propranolol also produces a decrease in order parameter of membrane lipids. The disordering effect is, however, small and detectable only at relatively high concentrations of the drug.
采用自旋标记技术研究了普萘洛尔对人红细胞膜结构的影响。在药物浓度与其对完整红细胞的抗溶血作用相对应时，检测了自旋标记膜蛋白的电子自旋共振光谱变化。光谱变化特征表明，普萘洛尔诱导的膜蛋白组织改变主要与位于膜表面的蛋白位点扰动有关。普萘洛尔还会使膜脂的序参数降低。然而，这种无序化作用较小，只有在相对高浓度的药物时才能检测到。
