Rubba P, Pezzella G, Rivellese A, Postiglione A
Atherosclerosis. 1982 Mar;42(1):31-40. doi: 10.1016/0021-9150(82)90123-x.
Decreased fatty acid and glucose incorporation into human adipose tissue (FIAT and GLIAT) are frequently found in primary hypertriglyceridemia (HTG) and might also contribute to the defective removal of lipoprotein triglyceride (TG) in non-insulin-dependent diabetes mellitus (NIDDM). To study this possible mechanism, FIAT and GLIAT were determined in needle biopsy specimens from 14 patients with newly diagnosed NIDDM and in 14 age- and weight-matched controls. A patient with insulinoma and hyperinsulinism was also studied. FIAT and GLIAT processes were markedly reduced in patients with NIDDM that developed at the onset of maturity. Insulinoma patients, with normal plasma TG, showed FIAT-GLIAT values in the high to normal range before operation. A direct, highly significant correlation (P less than 0.001) was demonstrated between FIAT and GLIAT in diabetics, insulinoma and controls when considered together. Plasma TG and glucose concentrations were inversely related to FIAT and GLIAT. These relationships were independent of the degree of obesity. It is suggested that impaired FIAT and GLIAT might contribute to defective TG removal and HTG which are often demonstrated in NIDDM.
在原发性高甘油三酯血症（HTG）中，经常发现脂肪酸和葡萄糖掺入人体脂肪组织（FIAT和GLIAT）减少，这也可能导致非胰岛素依赖型糖尿病（NIDDM）中脂蛋白甘油三酯（TG）清除缺陷。为了研究这种可能的机制，对14例新诊断的NIDDM患者以及14例年龄和体重匹配的对照者的针吸活检标本进行了FIAT和GLIAT测定。还研究了一名患有胰岛素瘤和高胰岛素血症的患者。在成年期发病的NIDDM患者中，FIAT和GLIAT过程明显减少。血浆TG正常的胰岛素瘤患者在手术前FIAT - GLIAT值处于高至正常范围。将糖尿病患者、胰岛素瘤患者和对照者一起考虑时，FIAT和GLIAT之间存在直接且高度显著的相关性（P小于0.001）。血浆TG和葡萄糖浓度与FIAT和GLIAT呈负相关。这些关系与肥胖程度无关。提示FIAT和GLIAT受损可能导致NIDDM中常见的TG清除缺陷和HTG。
