• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Salt-induced conformational changes in the catalytic subunit of adenosine cyclic 3',5'-phosphate dependent protein kinase. Use for establishing a connection between one sulfhydryl group and the gamma-P subsite in the ATP site of this subunit.

作者信息

Jiménez J S, Kupfer A, Gani V, Shaltiel S

出版信息

Biochemistry. 1982 Mar 30;21(7):1623-30. doi: 10.1021/bi00536a024.

DOI:10.1021/bi00536a024
PMID:6282311
Abstract
摘要

相似文献

1
Salt-induced conformational changes in the catalytic subunit of adenosine cyclic 3',5'-phosphate dependent protein kinase. Use for establishing a connection between one sulfhydryl group and the gamma-P subsite in the ATP site of this subunit.盐诱导的环磷腺苷依赖性蛋白激酶催化亚基的构象变化。用于建立该亚基ATP位点中一个巯基与γ-P亚位点之间的联系。
Biochemistry. 1982 Mar 30;21(7):1623-30. doi: 10.1021/bi00536a024.
2
On the protein accommodating site of the catalytic subunit of adenosine cyclic 3',5'-phosphate dependent protein kinase.关于腺苷环化3',5'-磷酸依赖性蛋白激酶催化亚基的蛋白质容纳位点。
Biochemistry. 1982 Mar 30;21(7):1631-7. doi: 10.1021/bi00536a025.
3
Purification and some properties of rabbit skeletal muscle fructose 6-phosphate kinase inhibitor.兔骨骼肌6-磷酸果糖激酶抑制剂的纯化及某些性质
Biochimie. 1975;57(6-7):683-94. doi: 10.1016/s0300-9084(75)80044-7.
4
Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.一种新型化合物N-[2-(甲氨基)乙基]-5-异喹啉磺酰胺(H-8)与环磷酸腺苷(cAMP)依赖性蛋白激酶活性位点的特异性结合。
Mol Pharmacol. 1987 May;31(5):523-8.
5
Modification and identification of glutamate residues at the arginine-recognition site in the catalytic subunit of adenosine 3' :5'-cyclic monophosphate-dependent protein kinase of rabbit skeletal muscle.兔骨骼肌3':5'-环磷酸腺苷依赖性蛋白激酶催化亚基中精氨酸识别位点处谷氨酸残基的修饰与鉴定
Biochem J. 1980 May 1;187(2):371-9. doi: 10.1042/bj1870371.
6
Apparent constants for the interaction of regulatory and catalytic subunit of cAMP-dependent protein kinase I and II.环磷酸腺苷依赖性蛋白激酶I和II的调节亚基与催化亚基相互作用的表观常数。
J Biol Chem. 1980 Feb 25;255(4):1559-64.
7
Specific inhibition of cyclic AMP-dependent protein kinase, adenylate cyclase and phosphodiesterase by ATP and cyclic AMP analogs.ATP和环磷酸腺苷类似物对环磷酸腺苷依赖性蛋白激酶、腺苷酸环化酶和磷酸二酯酶的特异性抑制作用。
Adv Enzyme Regul. 1978;17:251-82. doi: 10.1016/0065-2571(79)90016-5.
8
Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase.
J Biol Chem. 1977 Apr 25;252(8):2691-7.
9
[Interaction of N1-, N6- and C8-substituted derivatives of adenosine-5'-triphosphate with the catalytic subunit of cAMP-dependent protein kinase from rabbit skeletal muscles].[腺苷 - 5'-三磷酸的N1 -、N6 - 和C8 - 取代衍生物与兔骨骼肌中cAMP依赖性蛋白激酶催化亚基的相互作用]
Biokhimiia. 1982 Nov;47(11):1806-13.
10
Adenosine-3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. 3. Structural specificity of the ATP site of the catalytic subunit.
Can J Biochem. 1974 Feb;52(2):137-41. doi: 10.1139/o74-021.

引用本文的文献

1
RedOx regulation of LRRK2 kinase activity by active site cysteines.活性位点半胱氨酸对LRRK2激酶活性的氧化还原调节。
NPJ Parkinsons Dis. 2024 Apr 3;10(1):75. doi: 10.1038/s41531-024-00683-5.
2
Phosphorylation and Dephosphorylation of Tau Protein by the Catalytic Subunit of PKA, as Probed by Electrophoretic Mobility Retard.蛋白激酶 A 的催化亚基对 Tau 蛋白的磷酸化和去磷酸化作用的电泳迁移率变化探测
J Alzheimers Dis. 2021;79(3):1143-1156. doi: 10.3233/JAD-201077.
3
Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons.
中子束中的蛋白激酶A:通过直接观察质子获得的催化见解。
Methods Enzymol. 2020;634:311-331. doi: 10.1016/bs.mie.2019.12.003. Epub 2020 Jan 17.
4
Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.聚焦于质子:被捕获在产物复合物中的蛋白激酶 A 的中子结构。
Sci Adv. 2019 Mar 20;5(3):eaav0482. doi: 10.1126/sciadv.aav0482. eCollection 2019 Mar.
5
Long-range molecular dynamics show that inactive forms of Protein Kinase A are more dynamic than active forms.长程分子动力学表明,蛋白激酶 A 的非活性形式比活性形式更具动态性。
Protein Sci. 2019 Mar;28(3):543-560. doi: 10.1002/pro.3556. Epub 2018 Dec 30.
6
Dynamic architecture of a protein kinase.一种蛋白激酶的动态结构
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4623-31. doi: 10.1073/pnas.1418402111. Epub 2014 Oct 15.
7
A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry.通过毛细管液相色谱-质谱联用和串联质谱法检测到哺乳动物环磷酸腺苷依赖性蛋白激酶催化亚基中天冬酰胺2处的一个保守脱酰胺位点。
Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
8
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A.保守水分子有助于在蛋白激酶A活性位点形成广泛的相互作用网络。
Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):484-91. doi: 10.1073/pnas.95.2.484.
9
Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which 'buries' Ser-378, its site of phosphorylation by protein kinase A.玻连蛋白中精氨酸-379-丙氨酸-380肽键的内源性切割导致一种明显的构象变化,该变化“掩埋”了丝氨酸-378,即其被蛋白激酶A磷酸化的位点。
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):387-94. doi: 10.1042/bj2740387.
10
Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C.治疗性金化合物的免疫调节作用。硫代苹果酸金钠抑制T细胞蛋白激酶C的活性。
J Clin Invest. 1992 Jun;89(6):1839-48. doi: 10.1172/JCI115788.